Status:
COMPLETED
Predictors of HFNC Failure in Patients With AHRF Using Diaphragm Ultrasound
Lead Sponsor:
Queen Mary Hospital, Hong Kong
Conditions:
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18-100 years
Brief Summary
Ultrasound of the diaphragm is an easily reproducible bedside tool that provides a non-invasive measurement of inspiratory muscle function and respiratory efficiency. The diaphragmatic thickness corre...
Eligibility Criteria
Inclusion
- Age ≧ 18; AND
- Acute hypoxemic respiratory failure (AHRF), defined by respiratory rate of greater than 25 breaths per minute and a ratio of the PaO2 to the fraction of inspired oxygen (PaO2 / FiO2) of less than 300, and use of accessory muscles of respiration or paradoxical abdominal motion; AND
- Required ventilatory support with high-flow nasal cannula (HFNC)
Exclusion
- Patients suffering from hypercapnic respiratory failure; OR
- AHRF secondary to conditions that are indicated for non-invasive ventilation (NIV) (e.g. acute exacerbation of COPD, cardiogenic pulmonary edema); OR
- Use of NIV or invasive mechanical ventilation (IMV) prior to HFNC initiation; OR
- Patients with imminent need for endotracheal intubation and invasive mechanical ventilation (IMV); OR
- Patients with known or suspected diaphragm paralysis; OR
- Pregnancy; OR
- Patients with abdominal compartment syndrome; OR
- Use of HFNC for more than 12 hours prior to ICU admission; OR
- Patients with suboptimal diaphragm ultrasound image quality for data processing; OR
Key Trial Info
Start Date :
April 28 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06096376
Start Date
April 28 2023
End Date
September 1 2024
Last Update
October 17 2024
Active Locations (1)
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1
Queen Mary Hospital
Hong Kong, Hong Kong