Status:
UNKNOWN
Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance
Lead Sponsor:
Assiut University
Conditions:
Hypothyroidism
Insulin Resistance
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aim of the study is the effect of lifestyle modification and metformin on hypothyroidism with insulin resistance
Detailed Description
Hypothyroidism happens when the thyroid does not create and release enough thyroid hormone in the body this make the metabolism slow down . Thyroid hormones T3 and T4 maintain a fine balance of gluco...
Eligibility Criteria
Inclusion
- 1\_ above 18 years with insulin resistance criteria according (The American Association of Clinical Endocrinologists (AACE)
- 1)BMI of 25 kg/m2 or higher
- 2)Waist circumference of more than 102 cm in men or more than 88 cm in women
- 3)Triglyceride level of 150 mg/dl . or higher.
- 4\) HDL-C level of less than 40 mg/dl in men or less than 50 mg/dl in women
- 5)Blood pressure of 130 /85 mmhg or higher
- 6)Fasting glucose level of 110 ـ126 mg /dl
- 7)Glucose level of more than 140 mg/dl2 hour after administration of 75 g of glucose
- 2\_ Patients known to have hypothyroidism and achieving diagnostic criteria of insulin resistance
Exclusion
- Patients don't have other secondary causes of insulin resistance i.e. acromegaly, Cushing syndrome 3- patient have renal or hepatic impairment (contraindication to metformin )
Key Trial Info
Start Date :
November 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 30 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06096454
Start Date
November 20 2023
End Date
October 30 2024
Last Update
October 23 2023
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