Status:
RECRUITING
Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension
Lead Sponsor:
Medical University of Vienna
Conditions:
Arterial Hypertension
Blood Pressure, High
Eligibility:
All Genders
18-90 years
Brief Summary
To evaluate whether in patients with initially poorly-controlled arterial hypertension, structural and functional differences in the retina and choroid remain after achieving a well-controlled blood p...
Detailed Description
Optical Coherence Tomography Angiography (OCT-A) is an ocular imaging technique which allows fast and non-invasive assessment of the retinal microvasculature. With the OCT-A, a reduction in capillary ...
Eligibility Criteria
Inclusion
- Men and Women aged ≥ 18 years
- Signed informed consent
- Apart from hypertensive retinopathy, normal ophthalmic findings
- Non-Smokers
- Patients with initially diagnosed or pre-existing mild to moderate primary arterial hypertension (systolic office blood pressure ≥ 140 mmHg and/or diastolic office blood pressure ≥ 90 mmHg)
- Planned initiation of antihypertensive medication or planned adaption of antihypertensive medication by the Department of Cardiology
- Subject agrees to perform regular blood pressure self-measurements and to document blood pressure values in a diary
Exclusion
- Participation in a clinical trial in the three weeks preceding the study
- Blood donation in the three weeks preceding the study
- Symptoms of a clinically relevant illness in the three weeks preceding the study
- History of family history of epilepsy
- Secondary hypertension (e.g.: hyperaldosteronism, pheochromocytoma, renal artery stenosis, renal parenchymal diseases, Cushing-syndrome, Coarctatio aortae)
- History of hypertensive encephalopathy or intracerebral bleeding
- Diabetes mellitus Type 1 or Type 2
- Pregnant or breast-feeding women
- Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06098300
Start Date
September 1 2023
End Date
August 1 2025
Last Update
September 19 2024
Active Locations (1)
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1
Medical University of Vienna
Vienna, Austria, 1090