Status:
RECRUITING
Association Analysis of Cardiovascular and Nervous System Diseases and Intestinal Microbiome Based on Multi-omics Big Data and Related Applications
Lead Sponsor:
Tao Xin
Conditions:
Nervous System Diseases
Cardiovascular and Cerebrovascular Diseases
Eligibility:
All Genders
18-75 years
Brief Summary
Research purpose 1. Combined with multi-omics data and advanced data mining methods, we explored the pathogenesis and potential application pathway of intestinal microbiome mediated by specific cardi...
Detailed Description
A microbial ecosystem is a complex community of interacting bacteria. The potential role of intestinal flora in human health has attracted extensive attention. Imbalances in the gut microbiome have be...
Eligibility Criteria
Inclusion
- Inclusion criteria of idiopathic ventricular tachycardia:
- Idiopathic ventricular tachycardia and frequent ventricular premature were recorded by routine 12-lead electrocardiogram or 24-hour holter electrocardiogram. It can meet the clinical diagnostic criteria of idiopathic speed and frequent ventricular premature.
- 18 years ≤ age ≤75 years.
- Exclusion criteria for idiopathic ventricular tachycardia:
- Patients with coronary heart disease, myocardial infarction, valvular heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy, congenital heart disease, heart failure and other organic heart disease.
- Use of antibiotic drugs within 45 days.
- Case control inclusion criteria for idiopathic ventricular tachycardia:
- Routine 12-lead ECG or 24-hour holter ECG did not find idiopathic ventricular tachycardia and frequent ventricular premature.
- 18 years ≤ age ≤75 years.
- Case-control exclusion criteria for idiopathic ventricular tachycardia:
- Patients with coronary heart disease, myocardial infarction, valvular heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy, congenital heart disease, heart failure and other organic heart disease.
- Use of antibiotic drugs within 45 days.
- Inclusion criteria of postoperative coronary artery stenosis injury cases:
- Patients with confirmed coronary heart disease or history of coronary heart disease, after interventional treatment, stent implantation, and regular CTA review.
- 18 years ≤ age ≤75 years.
- Exclusion criteria for postoperative coronary artery stenosis injury cases:
- CTA found no vascular restenosis.
- Use of antibiotic drugs within 45 days.
- Inclusion criteria for case control of postoperative vascular stenosis injury in coronary heart disease:
- Confirmed coronary heart disease or history of coronary heart disease, after interventional treatment, stent implantation, CTA examination did not find restenosis of blood vessels.
- 18 years ≤ age ≤75 years.
- Case-control exclusion criteria for postoperative vascular stenosis injury of coronary heart disease:
- (1) Use of antibiotic drugs within 45 days.
- Inclusion criteria of moyamoya disease cases:
- Moyamoya disease was confirmed by imaging examination.
- 18 years ≤ age ≤75 years.
- Exclusion criteria for moyamoya disease cases:
- Previous history of vascular surgery or trauma
- Use of antibiotic drugs within 45 days.
- Inclusion criteria of moyamoya disease control cases:
- Imaging diagnosis confirmed no moyamoya disease.
- 18 years ≤ age ≤75 years.
- Exclusion criteria for control cases of moyamoya disease:
- Previous history of vascular surgery or trauma.
- Use of antibiotic drugs within 45 days.
- Inclusion criteria of carotid atherosclerosis cases:
- Carotid atherosclerosis was confirmed by ultrasound, CTA and other imaging examinations.
- 18 years ≤ age ≤75 years.
- Exclusion criteria for carotid atherosclerosis cases:
- Previous history of carotid vascular surgery or trauma.
- Use of antibiotic drugs within 45 days.
- Inclusion criteria for carotid atherosclerosis case control:
- Carotid ultrasound showed no atherosclerosis.
- 18 years ≤ age ≤75 years.
- Carotid atherosclerosis case-control exclusion criteria:
- Previous history of carotid vascular surgery or trauma.
- Use of antibiotic drugs within 45 days.
Exclusion
Key Trial Info
Start Date :
April 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
490 Patients enrolled
Trial Details
Trial ID
NCT06099496
Start Date
April 1 2023
End Date
April 30 2026
Last Update
October 25 2023
Active Locations (1)
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1
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, China