Status:
RECRUITING
Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Acute Ischemic Stroke
Basilar Artery Occlusion
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to assess the efficacy and safety of endovascular treatment versus medical management in patients with acute basilar artery occlusion with extended time window of 24-72 hours ...
Detailed Description
The ANGEL-BAO is a multicentered, prospective, randomized, open-label, blinded end-point clinical trial. A total of 224 patients with acute basilar artery occlusion with extended time window of 24-72 ...
Eligibility Criteria
Inclusion
- Age≥18 years
- Acute basilar artery occlusion confirmed by CTA, MRA, or DSA
- Pre-stroke mRS of 0-2
- NIHSS score ≥ 10 before randomization
- Time interval from symptom onset (or last known well) to randomization within 24-72 hours
- Diffusion-weighted imaging(DWI)-based pc-ASPECTS ≥ 6 and Pons-Midbrain Index (PMI) ≤3
- Time from completion of DWI imaging to randomization is ≤3 hours
- Each patient or their legal representative must provide written informed consent before enrolment
Exclusion
- Any sign of intracranial hemorrhage (except microbleeds) on brain imaging prior to randomization
- Complete cerebellar infarct with significant mass effect, or bilateral thalamic infarction as evidenced by baseline neuroimaging
- CT or MRI evidence of intracranial tumor (except small meningioma and cerebral aneurysm \< 3mm in diameter)
- Known or highly suspected chronic occlusion of basilar artery
- History of contraindication for contrast medium (except mild rash)
- Current pregnant or breast-feeding
- Known to have dementia or psychiatric disease unable to complete neurological assessment and follow-up
- Life expectancy is less than 3 months
- Enrolled in another drug or device trial or expected to participate in another drug or device treatment trial within the following 3 months.
- Any other condition (in the opinion of the site investigator) that inappropriate to participate this study
Key Trial Info
Start Date :
October 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
224 Patients enrolled
Trial Details
Trial ID
NCT06101667
Start Date
October 15 2023
End Date
December 1 2025
Last Update
June 13 2025
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070