Status:
RECRUITING
Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children
Lead Sponsor:
Columbia University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Obsessive-Compulsive Disorder in Children
Eligibility:
All Genders
8-12 years
Phase:
NA
Brief Summary
This study aims to examine the effects of a game-like program called cognitive control training (CT) for children with obsessive compulsive disorder (OCD). Children enrolled in this study will receive...
Detailed Description
Obsessive-Compulsive Disorder (OCD) often onsets in childhood and, if not effectively treated, can lead to lifelong illness and poor functional outcomes. Cognitive behavioral therapy (CBT) with exposu...
Eligibility Criteria
Inclusion
- Ages between 8 and 12 years;
- Clinically significant OCD as the principal problem. This is defined as follows: they must meet DSM-V criteria for OCD as assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Version (K-SADS-PL). OCD must be the primary source of interference and distress (based on clinical evaluation with K- SADS-PL and Children's Yale-Brown Obsessive Compulsive Scale (C-YBOCS) and they must have clinically significant symptoms (i.e., C-YBOCS) ≥ 16;
- Not on psychotropic medication (either treatment-naïve or free of psychotropic medication for at least three months) and not receiving current psychotherapy for OCD;
- Ability to tolerate a treatment-free period (i.e., no treatment other than study CBT);
- Capacity to provide informed assent
Exclusion
- Current or past diagnosis of major depressive disorder, PTSD, substance/alcohol abuse, psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, substance/alcohol dependence, or any other Axis I disorder not listed above;
- Active suicidal ideation;
- Females who are pregnant or nursing;
- Any major medical or neurological problem (e.g., unstable hypertension, seizure disorder, head trauma); -Positive urine screen for illicit drugs;
- Presence of metallic device or dental braces;
- IQ \<80;
Key Trial Info
Start Date :
June 27 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06102941
Start Date
June 27 2024
End Date
August 1 2026
Last Update
November 6 2025
Active Locations (1)
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1
Columbia University Irving Medical Center
New York, New York, United States, 10032