Status:
RECRUITING
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
Mclean Hospital
Beth Israel Deaconess Medical Center
Conditions:
Appetitive Behavior
Obesity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic fie...
Detailed Description
The purpose of this study is to conduct a circuit manipulation experiment to test the hypothesis that targeting the cerebellum can alter activity in response to food cues to advance the understanding ...
Eligibility Criteria
Inclusion
- Healthy individuals aged 18 to 65
- BMI of 20-35.0 kg/m2
- Normal or corrected-to-normal vision
- Good general health
- Ability to understand and willingness to sign written informed consent document
Exclusion
- Current and/or past medical conditions
- Current and/or past eating disorder
- On a restricted diet and/or taking weight loss medication(s)
- History of bariatric surgery
- Weight fluctuation \>3% in past 3 months
- Recent history of illicit recreational drug abuse
- Current nicotine use
- Intellectual disability
- Conditions that might result in increased risks of side effects or complications from TMS or MRI
Key Trial Info
Start Date :
December 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2029
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06105164
Start Date
December 5 2024
End Date
August 1 2029
Last Update
December 5 2025
Active Locations (2)
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1
McLean Hospital
Belmont, Massachusetts, United States, 02478
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02120