Status:
RECRUITING
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
Lead Sponsor:
University of Texas, El Paso
Conditions:
Knee Osteoarthritis
Knee Pain Chronic
Eligibility:
All Genders
45-90 years
Phase:
NA
Brief Summary
The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and kne...
Detailed Description
This will be a pilot randomized cross-over study. Major exclusion criteria will be conditions that have risks with exercise or affect pain assessments. Once enrolled, all participants will undergo 3 l...
Eligibility Criteria
Inclusion
- Participants with knee OA (Target n=40)
- We will recruit participants with knee OA, using the National Institute for Health and Care Excellence's clinical diagnostic criteria, which does not require radiographs. The clinical diagnostic criteria include:
- age ≥45
- activity-related knee pain
- either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.
- knee pain at least 4 on a 0-10 pain scale
- knee pain as a chief complaint if having multiple pain
- understand English
Exclusion
- peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)
- use of medical devices electrically active (e.g., pacemaker)
- chronic use of opioids
- pregnant women
- serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine, gastrointestinal or epileptic disease
- rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure
- cognitive impairment
- history of a knee replacement surgery
- inability to perform exercise due to severe pain or other symptoms
- any intervention procedures for knee pain in the last 3 months
- Inclusion and exclusion criteria for pain-free controls (Target n = 20) Pain-free controls are not having a pain-related medical condition. They have to speak and understand English. Pain-free controls are excluded if they had experienced a pain episode, caused by musculoskeletal injury or otherwise in the previous 3 months.
Key Trial Info
Start Date :
November 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 16 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06105788
Start Date
November 15 2023
End Date
October 16 2025
Last Update
December 16 2024
Active Locations (1)
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1
The University of Texas at El Paso
El Paso, Texas, United States, 79968