Status:
NOT_YET_RECRUITING
Improved Diagnostics, Treatment and Follow-up of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Vestre Viken Hospital Trust
Conditions:
Chronic Obstructive Pulmonary Disease Exacerbation
Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive pulmonary disease, where inflammation and recurrent infections are key pathophysiological contibutors in disease progres...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Admitted to the emergency room with a tentative diagnosis of AECOPD, and at least two of the following criteria, more than the daily variation,
- Increased dyspnea
- Increased cough
- Increased sputum production
- Need for change in medication due to AECOPD
- Signed informed consent. Among patients with temporal or permanent reduced ability to consent, close relatives and/or family members must be asked and may approve or reject participation on behalf of the patient. In cases where close relatives/family members are not available, study personnel may include patients according to conscious judgment.
- Patients will be informed about the study and included by dedicated and approved study personnel (study nurses or study doctors), not by the treating health personnel.
Exclusion
- Pulmonary embolism, segmental or larger
- Refractory septic shock (meeting the Sepsis-3 definition of septic shock, and requiring vasopressors ≥ 0.5 mcg/kg/min noradrenaline or equivalent dose of other vasopressor(s)
- Glasgow Coma Scale score 3
- Patients not eligible for lower airways sampling within the first 24 hours of admission
- Palliative situation with life expectancy \< 1 week
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06105814
Start Date
January 1 2024
End Date
December 31 2030
Last Update
October 30 2023
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