Status:
NOT_YET_RECRUITING
CAR-T Cell Induced Cardiac Dysfunction: A Prospective Study
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Lymphoma
Eligibility:
All Genders
18+ years
Brief Summary
In this observational, prospective study, patients affected by B-cell Lymphoma and candidate to chimeric antigen receptor-T (CAR-T) cell infusion will be evaluated at three timepoints to establish the...
Detailed Description
Patients will perform clinical evaluation, transthoracic echocardiogram with speckle tracking analysis and blood samples (including cardiac biomarkers of damage and fibrosis) prior to CART infusion, a...
Eligibility Criteria
Inclusion
- Age\>18 years old;
- Patients affected by relapsed and/or refractory diffuse large B-cell lymphoma, follicular lymphoma, primary mediastinal B-cell lymphoma, mantle cell lymphoma or B-cell lymphoblastic leukemia, candidate treatment with chimeric antigen receptor-T cell therapy at the Hematology division of Policlinico Universitario Agostino Gemelli, Rome;
- Patients with left ventricular ejection fraction \>50%.
Exclusion
- Age\<18 years old;
- Patients who denied to participate to the study;
- Patients with left ventricular ejection fraction\<50%.
Key Trial Info
Start Date :
November 2 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2026
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06106776
Start Date
November 2 2023
End Date
January 31 2026
Last Update
October 30 2023
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