Status:
TERMINATED
Maimonides Minocycline in Stroke Study
Lead Sponsor:
Maimonides Medical Center
Conditions:
Stroke, Acute
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The goal of this study is to determine if oral Minocycline's proposed neuroprotective effects further improve the clinical outcomes, including mortality, of acute stroke patients beyond the current st...
Detailed Description
Studies on animals and humans have shown that Minocycline, a widely used semi-synthetic antibiotic, may protect the brain, spinal cord and nervous system from injuries such as ischemia, trauma, neurod...
Eligibility Criteria
Inclusion
- Age \>/=18
- Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO (World Health Organization) guidelines
- Acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed
- The onset of symptoms less than 24 hours
- Measurable neurological deficit using NIHSS (National Institutes of Health Stroke Scale )
Exclusion
- Clinically not suspect stroke.
- Allergic to the Tetracycline group of medications or Intolerance to Minocycline
- Pregnancy or suspected pregnancy
- Previous history of intolerance to minocycline
- Acute or chronic renal failure
- Any patients with contraindications to undergo CT/ MRI
- Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission
- Pre-existing infectious disease requiring antibiotics
- Inability to tolerate enteral medications/feeds
- Patient/ family refusal
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 9 2024
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT06107725
Start Date
November 1 2023
End Date
May 9 2024
Last Update
December 17 2025
Active Locations (1)
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1
Maimonides Medical Center
Brooklyn, New York, United States, 11219