Status:
RECRUITING
Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment
Lead Sponsor:
University of Utah
Collaborating Sponsors:
Huntsman Cancer Institute
Conditions:
Head and Neck Cancer
Hypoxia
Eligibility:
All Genders
18+ years
Brief Summary
Tumor hypoxia is one of the physiological factors for treatment resistance and likely contributes to poor overall survival among patients with head and neck cancer (HNC). Identifying hypoxic features ...
Detailed Description
The objectives of this feasibility study are; 1) To obtain pilot data for a full-scale study and measure the distribution of parameters of the hypoxia MR (perfusion, diffusion, oxygenation, and acidos...
Eligibility Criteria
Inclusion
- Newly diagnosed HNSCC (head and neck squamous cell carcinoma) by biopsy or fine needle aspiration originating from the oral cavity, larynx, hypopharynx, nasopharynx, and oropharynx
- Patients are scheduled to undergo chemoradiotherapy or surgery
- Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines.
Exclusion
- Pregnant patients
- Patients with claustrophobia
- Patients with pacemaker, spinal stimulator, or cochlear implant that are not MR compatible or any other metallic objects in the body
- Patients who had been treated for HNC, either surgery, radiation therapy, or chemotherapy
- Patients with thyroid, skin, sinonasal, and salivary gland cancer.
- Abnormal kidney function defined as estimated glomerular filtration rate (eGRF) \< 30 mL/min/1.73 m2
- Patients with uncontrolled diabetes
- Patients who obtained outside FDG-PET/CT prior to initial treatment
Key Trial Info
Start Date :
June 28 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06108089
Start Date
June 28 2024
End Date
December 1 2025
Last Update
August 12 2024
Active Locations (1)
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1
University of Utah
Salt Lake City, Utah, United States, 84112