Status:
RECRUITING
Cerebellar Involvement in Cognitive Sequencing
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Effects of Cerebellar Stimulation on Brain Activation
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory th...
Detailed Description
Although there is increasing recognition that the cerebellum, which contains half of the brain's neurons, is involved in cognition as well as motor function, the manner in which the cerebellum contrib...
Eligibility Criteria
Inclusion
- 1\) Age 18-50;
- 2\) educational attainment of at least 8 years;
- 3\) capable of giving informed consent;
- 4\) fluent speaker of English by self-report;
- 5\) right handed.
Exclusion
- 1\) illicit drug use within 30 days of MRI scanning;
- 2\) neurological or systemic disorder which can cause dementia or cognitive dysfunction;
- 3\) history of an Axis I psychiatric disorder including substance use disorder;
- 4\) history of definite stroke;
- 5\) focal lesion on MRI exam;
- 6\) uncorrected visual deficits by self-report
- 7\) contraindications for MRI scanning
- 8\) use of anxiolytic, antidepressant, neuroleptic, or sedative medication
- 9\) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease
Key Trial Info
Start Date :
March 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06108336
Start Date
March 1 2024
End Date
July 31 2027
Last Update
January 15 2025
Active Locations (1)
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1
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21205