Status:
RECRUITING
Clearance of Vasoactive Metabolites With Blood Purification
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Critically Ill Patients
Eligibility:
All Genders
6+ years
Brief Summary
Extracorporeal blood purification is a supportive therapy in the management of patients with sepsis or vasoplegic shock. The pathophysiology of sepsis is based on an inappropriate host response to inf...
Detailed Description
This is a pilot study, non-interventional research involving the human subjects, category 3, aimed at measuring the clinical and biological the clinical and biological effects of using the oXiris hemo...
Eligibility Criteria
Inclusion
- Patients admitted to intensive care with vasoplegic shock (hemodynamic support by noradrenaline).
- Adult or child ≥ 6 years and 30kg
- Indication for extrarenal purification for acute, chronic renal failure, oliguric hydrosodic overload, refractory metabolic acidosis or severe hydroelectrolyte disorder
- Clinician's decision to use an oXiris hemofilter with blood purification capability
- For adult patients: no opposition from the patient (or person of trust or close friend if the patient is unable to be informed)
- For minor patients: no opposition of the holders of parental authority
Exclusion
- No need for hemofiltration.
- Citrate anticoagulation of the hemofiltration circuit
- Inclusion in a category 1 or 2 interventional study protocol. Patients included in category 3 interventional research will be able to participate in the study after assessment by the physician.
- Patient under judicial protection and adults under guardianship or curatorship.
- Patient with no social security affiliation
Key Trial Info
Start Date :
July 11 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 11 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06109142
Start Date
July 11 2024
End Date
June 11 2026
Last Update
September 19 2024
Active Locations (3)
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1
Garches hospital
Garches, France, 92380
2
Bicetre hospital
Le Kremlin-Bicêtre, France, 94250
3
Hôpital Paul Brousse
Villejuif, France, 94800