Status:
COMPLETED
Efficacy, Transfer, and Neuro-functional Basis of a Memory Training Targeting Episodic Retrieval in Older Adults.
Lead Sponsor:
Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Natural Sciences and Engineering Research Council, Canada
Conditions:
Healthy
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
Aging leads to cognitive changes that affect memory, particularly episodic retrieval. These impairments are detrimental to seniors' quality of life. Cognitive trainings are of great interest to the sc...
Detailed Description
Aging leads to cognitive changes that affect memory, particularly episodic retrieval, which is involved in remembering an event within a specific spatio-temporal context. These impairments are detrime...
Eligibility Criteria
Inclusion
- French-speaking
- Right-handed
- Sufficient visual and auditory acuity to undergo neuropsychological tests and to do the interventions.
- Sufficient delayed recall score above the education-adjusted cut-offs (≥9 for 16+ years of education; ≥5 for 8-15 years of education; ≥3 for 0-7 years of education) at the Logical Memory test (Wechsler Memory Scale, maximum score 25).
Exclusion
- A score bellow the education-adjusted cut-offs at the MoCA ( \<24 for \>12 years of education; \<23 for = or \<12 years of education)
- Answer 'Yes' to the two following questions: "Do you feel like your memory is becoming worse?" "Does this worry you?" (to exclude subjective cognitive decline).
- The presence of a disease or injury of the central nervous system: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, subdural hematoma (past or current), subarachnoid haemorrhage (past or current), primary cerebral tumour or cerebral metastases, epilepsy (current), dementia or another neurodegenerative disease, and other rarer brain illnesses.
- Symptomatic stroke within the previous year.
- Alcoholism or substance abuse
- History of intracranial surgery.
- Major surgery within last 2 months.
- General anesthesia in the past 6 months.
- Serious comorbid condition that, in the opinion of the study investigator, is likely to result in death within a year.
- Major depression or anxiety.
- Schizophrenia or other major psychiatric disorder (e.g., bipolar disorder).
- Individuals where French is not sufficiently proficient for clinical assessment and neuropsychological testing.
- Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure.
- Plans on moving outside the province within the next 2 months.
Key Trial Info
Start Date :
September 22 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 29 2024
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT06110234
Start Date
September 22 2023
End Date
February 29 2024
Last Update
August 1 2024
Active Locations (1)
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1
CRIUGM
Montreal, Quebec, Canada, H3W 1W4