Status:
RECRUITING
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
Lead Sponsor:
University of Cambridge
Conditions:
Cancer
Cachexia
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aim...
Detailed Description
Cancer cachexia is a complex disorder involving progressive loss of muscle and fat in people with cancer, which cannot be corrected with dietary supplements. It affects 50-80% of the cancer population...
Eligibility Criteria
Inclusion
- General inclusion criteria for all groups:
- Written informed consent
- Aged 18 years or over
- Willing and able to comply with study procedures and visits
- Additional inclusion criteria for participants with cancer:
- Histological or cytological diagnosis of cancer or confirmed non-intracranial malignancy on imaging.
- Unintended documented weight loss of \>5% body weight in 6 months which is felt to be cancer related, OR patient reported weight loss and/or change in appetite
Exclusion
- General exclusion criteria for all groups:
- Non-fluent English speaker
- Active infection, as determined by the investigator based on clinical symptoms and / or fever and / or requirement for antibiotics
- Women, who are pregnant, plan to become pregnant or are lactating.
- MRI contraindication
- A significant acute, chronic or psychiatric condition which in the judgement of the investigator would place the volunteer at undue risk or interfere with the study
- Metabolically or clinically unstable on day of study visit
- Artificial nutrition
- Taking medications which, as determined by the investigator, may affect appetite or cognition, or otherwise affect completion of study tasks.
- Weight or body circumference above upper threshold for MRI scanner (220kg)
- Unresolved obstructive gastrointestinal (GI) lesion
- Additional exclusion criteria for participants with cancer:
- • Intracranial cancer or metastatic intracranial involvement of cancer
- Additional exclusion criteria for healthy volunteers:
- Have, or be recovering from, any form of cancer
- Unintentional weight loss of \>5% body weight or unexplained loss of appetite
Key Trial Info
Start Date :
February 15 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06112964
Start Date
February 15 2024
End Date
November 1 2027
Last Update
July 17 2024
Active Locations (1)
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1
University of Cambridge
Cambridge, United Kingdom, CB20QQ