Status:
COMPLETED
Head Position After Endovascular Therapy
Lead Sponsor:
Zhengzhou Yuan
Conditions:
Stroke, Acute
Endovascular Therapy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this trial is to investigate whether head elevation position after endovascular treatment can improve the 90-day functional outcome of acute large vessel occlusion in the anterior circulati...
Detailed Description
The optimal head position for patients with acute ischemic stroke (AIS) remains uncertain. The HeadPoS study revealed that there is no significant difference in disability outcomes between patients wh...
Eligibility Criteria
Inclusion
- Clinical signs consistent with acute ischemic stroke;
- Age ≥ 18 years old;
- Proved anterior circulation large vessel occlusion on digital subtraction angiography (ICA, M1, M2) with/without cervical lesion (tandem);
- NIHSS score ≥ 8 points before endovascular treatment;
- ASPECTS score ≤ 7 points before endovascular treatment;
- Successful vessel recanalization after endovascular treatment (defined as an eTICI score of 2b, 2c, or 3) ；
- The time from onset to randomization ≤ 24 hours (the onset time is defined as the last normal time);
- Written informed consent is obtained from patients and/or their legal representatives.
Exclusion
- Pre-stroke mRS score\>1 point;
- Patients with acute occlusions in multiple vascular territories (e.g. bilateral anterior circulation, or anterior/posterior circulation);
- Currently in pregnant or lactating or serum beta HCG test is positive on admission;
- Contraindications to a flat head position;
- Any terminal illness with life expectancy less than 6 months;
- Participating in other clinical trials;
- Patients with a preexisting neurological or psychiatric disease that would confound the neurological functional evaluations;
- Unlikely to be available for 90-day follow-up.
Key Trial Info
Start Date :
November 13 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 26 2025
Estimated Enrollment :
1368 Patients enrolled
Trial Details
Trial ID
NCT06115707
Start Date
November 13 2023
End Date
April 26 2025
Last Update
November 28 2025
Active Locations (67)
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1
Chongqing Banan District People's Hospital
Chongqing, Chongqing Municipality, China
2
Chongqing Bishan District People's Hospital
Chongqing, Chongqing Municipality, China
3
Chongqing Ninth People's Hospital
Chongqing, Chongqing Municipality, China
4
Yongchuan Hospital Affiliated to Chongqing Medical University
Chongqing, Chongqing Municipality, China