Status:
NOT_YET_RECRUITING
Hodgkin's Disease and Chemotherapy Before 40 Years
Lead Sponsor:
Lille Catholic University
Conditions:
Hodgkin Disease
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
A few studies have focused on other solid cancers (colorectal, prostate). On the other hand, the study of cognitive impairment in Hodgkin's disease remains less developed, and structural and functiona...
Detailed Description
Hodgkin's disease is a neoplasia of lymphoid tissue characterized by the characteristic presence of Reed Sternberg cells. This disease is preferentially affecting young patients under the age of 40. I...
Eligibility Criteria
Inclusion
- Inclusion criteria - case :
- Patient with newly diagnosed Hodgkin's disease
- With intention to treat with chemotherapy +/- radiotherapy
- Aged between 18 and 40 years
- Fluency in French
- Able to undergo neuropsychological evaluation (absence of major sensory disorders)
- Agreeing to take part in the study and having signed the informed consent form
- Affiliated with a social security scheme
- Inclusion criteria - controls:
- Individual without Hodgkin's disease
- Aged between 18 and 40
- Proficient in French
- Agreeing to participate in the study and having signed the informed consent form
- Affiliated with a social security scheme
- Cases and controls will be matched on age (± 5 years difference), and number of years of education (difference ≤ 2 years).
- Non-inclusion criteria - cases + controls :
- Claustrophobia preventing MRI from being performed
- Contraindication to MRI
- Previous chemotherapy
- History of neurological or psychiatric illness, including severe depression, or cognitive impairment
- Use of medications that may cause neurological or psychiatric signs
- Alcohol or drug abuse
- Pregnant women
- Persons under guardianship or trusteeship
Exclusion
Key Trial Info
Start Date :
May 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2028
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT06116929
Start Date
May 15 2024
End Date
January 1 2028
Last Update
February 28 2024
Active Locations (4)
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1
Centre Hospitalier Artois Ternois
Arras, France
2
Hôpital Claude Huriez
Lille, France
3
Hôpital Saint-Philibert
Lomme, France
4
Hôpital Victor Provo
Roubaix, France