Status:
RECRUITING
The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
Lead Sponsor:
Jasper Gerritsen
Collaborating Sponsors:
Haaglanden Medical Centre
Universitaire Ziekenhuizen KU Leuven
Conditions:
Glioblastoma
High-grade Glioma
Eligibility:
All Genders
18-90 years
Brief Summary
A greater extent of resection of the contrast-enhancing (CE) tumor part has been associated with improved outcomes in high-grade glioma patients. Recent results suggest that resection of the non-contr...
Detailed Description
This is an international, multicenter, prospective, observational, 2-arm cohort study (registration: clinicaltrials.gov ID number TBA). Eligible patients are operated with supramaximal resection versu...
Eligibility Criteria
Inclusion
- Age ≥18 years and ≤90 years
- Tumor diagnosed as HGG (WHO grade III/IV) on MRI as assessed by the neurosurgeon
- Written informed consent
Exclusion
- Tumors of the cerebellum, brainstem or midline
- Multifocal contrast enhancing lesions
- Medical reasons precluding MRI (e.g. pacemaker)
- Inability to give written informed consent
- Secondary high-grade glioma due to malignant transformation from low-grade glioma
- Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2028
Estimated Enrollment :
784 Patients enrolled
Trial Details
Trial ID
NCT06118723
Start Date
January 1 2022
End Date
January 1 2028
Last Update
February 22 2024
Active Locations (8)
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1
University of California, San Francisco (UCSF)
San Francisco, California, United States, 94143
2
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
3
University Hospitals Leuven
Leuven, Belgium, 3000
4
Universitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, Germany, 69120