Status:
UNKNOWN
CT Myocardial Perfusion to Guide the Diagnosis and Treatment of Patients With Stable Coronary Artery Disease (POTENTIAL)
Lead Sponsor:
Chinese Academy of Medical Sciences, Fuwai Hospital
Conditions:
Treatment Decision, Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The overall goal of this project is to compare the non-revascularization rate of coronary angiography in patients with stable coronary artery disease (CAD) within 90 days after CT myocardial perfusion...
Detailed Description
Participants will be patients with proven coronary artery disease (CAD) who are scheduled randomized to undergo CT Myocardial Perfusion Imaging (CT-MPI) or Single-Photon Emission Computed Tomography m...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Patients with stable chest pain who have undergone coronary CT angiography and have 50-90% stenosis in at least one vessel \> 2mm in diameter
- Able to provide signed informed consent
Exclusion
- Suspected or confirmed acute coronary syndrome
- Evidence of clinical instability or need for an emergent procedure
- History of percutaneous coronary stent implantation, history of coronary artery bypass grafting, or history of myocardial infarction
- Left main artery stenosis ≥ 50%
- Severe heart failure (New York Heart Association (NYHA) ≥III)
- Estimated glomerular filtration rate \< 60 mL/min/1.73 m2
- Contraindicated to use contrast agents, beta-blockers, nitrates or adenosine drugs
- Acute episodes of bronchial asthma or chronic obstructive pulmonary disease
- II or III degree atrioventricular block
- History of pacemaker or implantable cardioverter defibrillator implantation
- Combined with other cardiovascular diseases including cardiomyopathy, congenital heart disease, valvular heart disease, pulmonary vascular disease, pericardial disease, etc
- Pregnant or trying to be pregnant
- Combined with any other serious disease, life expectancy \<1 year
- Any condition leading to possible inability to comply with the protocol procedures and follow-up
- Currently participating in any other clinical trials
Key Trial Info
Start Date :
September 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
660 Patients enrolled
Trial Details
Trial ID
NCT06119022
Start Date
September 30 2023
End Date
December 31 2025
Last Update
November 7 2023
Active Locations (4)
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1
Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
2
Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, China
3
The First Affiliated Hosptial of Zhengzhou University
Zhengzhou, Henan, China
4
The Second Norman Bethune Hospital of Jilin University
Changchun, Jilin, China