Status:
RECRUITING
Phe for Me? The Effects of L-Phe on PKU Carriers and Non-carriers
Lead Sponsor:
University of Guelph
Collaborating Sponsors:
McMaster University
Laval University
Conditions:
Autosomal Recessive Disorder (Genetic Carriers of PKU)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a clinical intervention study of PKU carriers (cases) and non-carriers (controls). Upon completing the informed consent process, participants will complete baseline measures of chronic mental ...
Eligibility Criteria
Inclusion
- Carrier or non-carrier of PKU
- At least 18 Years of age
- Comfortable fasting the morning of the study (no food or drink other than water)
Exclusion
- Diagnosed with: PKU, severe neurodegenerative conditions affecting cognition (e.g. Alzheimer's, Parkinson's, dementia), melanoma, hypertension, liver disease and/or kidney disease
- Diagnosed with hypertension or hypotension
- Taking a monoamine oxidase inhibitor anti-depressant
- Pregnant or breastfeeding
- Orange/citrus allergy or intolerance
- Body weight 150 kg or greater
- History of fainting during blood sampling
Key Trial Info
Start Date :
June 18 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06119048
Start Date
June 18 2024
End Date
December 1 2025
Last Update
May 15 2025
Active Locations (2)
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1
University of Guelph
Guelph, Ontario, Canada, N1G 2W1
2
University of Guelph
Guelph, Ontario, Canada, N1G 2W1