Status:
RECRUITING
Effect of Visual Retraining After Stroke
Lead Sponsor:
University of Rochester
Conditions:
Vision Loss Partial
Vision; Loss, Both Eyes
Eligibility:
All Genders
21-80 years
Phase:
NA
Brief Summary
This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual percept...
Eligibility Criteria
Inclusion
- Cortically Blind Subjects
- Inclusion:
- Between 21 and 80 years of age
- Residents of the United States or Canada
- Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years)
- Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and/or equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus.
- Able to fixate on visual targets reliably for 1000ms
- Must have a home computer (desktop or laptop) and reliable internet access
- Willing, able, and competent to provide informed consent
- Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months.
- Exclusion:
- Past or present eye disease interfering with visual acuity
- BCVA worse than 20/40 in either eye
- Damage to the dorsal Lateral Geniculate Nucleus
- Diffuse whole brain degenerative processes
- History of traumatic brain injury
- Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures
- Documented history of drug/alcohol abuse
- Currently taking neuroactive medications which would impact training, as determined by PI
- Presence of cognitive or seizure disorders
- One-sided attentional neglect
- Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.
- Control Subjects (n = 50)
- Inclusion:
- Between 21 and 80 years of age
- Report no history of neurological disorder.
- Competent and responsible, as determined by the Principal Investigator.
- Exclusion:
- Presence of damage to the visual system
- Presence of an active disease process involving their nervous system.
- Cognitive or seizure disorders
- Best corrected visual acuity worse than 20/40 in either eye
- Presence of vision field loss from ocular disease or disorder
Exclusion
Key Trial Info
Start Date :
September 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2032
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06121219
Start Date
September 5 2024
End Date
January 1 2032
Last Update
July 16 2025
Active Locations (1)
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1
University of Rochester Medical Center
Rochester, New York, United States, 14642