Status:
UNKNOWN
Brain MRI Imaging Changes and Associated Factors on Cognition Function in Patients With Premature Ovarian Failure
Lead Sponsor:
International Peace Maternity and Child Health Hospital
Conditions:
Premature Ovarian Failure
Eligibility:
FEMALE
18-40 years
Brief Summary
The purpose of this study is to investigate the brain MRI imaging changes and associated factors on cognition function in patients with premature ovarian failure.
Detailed Description
Premature Ovarian Failure (POF) refers to a disease characterized by amenorrhea, infertility, low estrogen levels, and high gonadotropin concentration in women before the age of 40. In recent years, t...
Eligibility Criteria
Inclusion
- 1\. Criteria for premature ovarian failure:
- Subjects must meet all the following criteria to be included in the study:
- Female, between 18 and 40 years old;
- FSH ≥ 40U/L on two occasions at least four weeks;
- Sign informed consent. 2. Criteria for the health control group: According to the case control principle, at the same time, the investigators select women with similar age, BMI, working environment, education level and regular menstrual cycle in our hospital, and conduct endocrine examination (FSH \<10U/L) for health examination.
Exclusion
- Pregnancy or lactation;
- Patients with secondary ovarian insufficiency (such as causes of the hypothalamus);
- Chromosomal karyotype abnormalities (such as Turner syndrome, brittle X syndrome);
- Any disease that requires immediate blood transfusion;
- Abuse of alcohol, drugs or drugs (for example, laxatives)
- Allergies to MRI contrast agents;
- Accompanied by metal implants, claustrophobia and other magnetic resonance scanning contraindications;
- Accompanied by serious brain organic diseases, such as epilepsy, stroke, encephalitis, brain trauma, and so on. Nervous system diseases, such as Parkinson's disease, have other cognitive-impacting diseases, or serious somatic diseases such as malignant tumors, acute heart failure, multi-organ failure, and so on.
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06121388
Start Date
January 1 2023
End Date
December 31 2025
Last Update
November 14 2023
Active Locations (1)
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1
The International Peace Maternity and Child Health Hospital
Shanghai, Shanghai Municipality, China, 200030