Status:
COMPLETED
Thermogenic Effect and Metabolic Responses of Durian
Lead Sponsor:
Singapore Institute of Food and Biotechnology Innovation
Conditions:
Effects of; Food
Thermogenesis
Eligibility:
All Genders
21-40 years
Phase:
NA
Brief Summary
The primary aim of this study is to determine the effectiveness of durian on thermic effect of food (TEF), blood pressure, heart rate and postprandial glucose and lipid levels in young healthy men and...
Detailed Description
Visit 1: Consenting and screening for study criteria. Visit 1 consists of consenting and screening session. Potential subjects will arrive at CNRC at 8h30 after 10-hour overnight fast (at least), only...
Eligibility Criteria
Inclusion
- BMI with the range of 18-25 kg/m2
- Aged between 21 and 40 year-old
- Chinese origin
- Non-diabetic, fasting blood glucose ≤ 5.6 mmol/L
- Blood pressure below 140/90 mmHg
- Pass the general health screening questionnaire
- Have a stable bodyweight (\<5%) over the past 6 months
- Have no medical history
- Have ability to provide informed consent
Exclusion
- Subjects who are smoker or currently on nicotine therapy
- Subjects who regularly consume alcohol (\>1 unit per day)
- Subjects who are currently receiving therapy (e.g. insulin) or any medication/treatment (including supplements) that may affect glucose and lipid metabolism, energy metabolism or body composition.
- Subjects who are currently on steroids, protease inhibitors, or antipsychotic therapies
- Subjects who recently had a major medical or surgical event or will have one during the study period
- Subjects who have symptomatic Irritable Bowel Syndrome
- Subjects who have glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Subjects who have active Tuberculosis (TB) or currently receiving treatment for TB
- Subjects who have chronic infection or is known to suffer from or has previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- Subjects who participated in drug trial within 3 months before the start of the study
- Subjects who have allergy or intolerant to durian or/and banana
- Subjects who are unwilling to consume durian or banana
- Subjects who are hemophobia, trypanophobia, or claustrophobia
- Subjects (females) who are pregnant (pregnancy test will be performed), lactating, or planning to become pregnant during the study period
- Subjects who do not have adequate fluency in the English language
- Subjects who are unable to understand the study procedures and to sign forms providing written informed consent to participate in the study
- Subjects who are a member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted
Key Trial Info
Start Date :
July 19 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2024
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06121817
Start Date
July 19 2023
End Date
March 1 2024
Last Update
May 16 2024
Active Locations (1)
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1
Clinical Nutrition Research Centre (CNRC)
Singapore, Singapore, 117599