Status:
RECRUITING
Study of HS-10384 in Participants of Chinese Postmenopausal Women
Lead Sponsor:
Hansoh BioMedical R&D Company
Conditions:
Vasomotor Symptoms
Eligibility:
FEMALE
40-65 years
Phase:
PHASE1
Brief Summary
A randomized, double-blind, placebo-controlled phase Ib clinical study to evaluate the safety, tolerability and pharmacokinetics characteristics of HS-10384 in Chinese postmenopausal women.
Detailed Description
Phase Ib is consisted with 3\~4 multiple ascending doses.
Eligibility Criteria
Inclusion
- Subjects should fully understand the content, process and possible adverse reactions of the study, and voluntarily sign the informed consent form;
- Age between 40 and 65 years old (including the critical value);
- The body mass index (BMI=body weight \[kg\]/height2 \[m2\]) at screening is 19\~28 kg/m2 (including the critical value of 19), and the weight is ≥ 40 kg;
- Subjects are postmenopausal women at screening as qualified by any of the following criteria: spontaneous amenorrhea ≥ 12 months, or spontaneous amenorrhea ≥ 6 months and FSH\>40 IU/L (without other obvious pathological or physiological reasonsbefore screening), or documented surgical sterilization (such as hysterectomy, bilateral salpingectomy or bilateral oophorectomy, etc.);
- From 48 hours before taking drug to the end of the study, subjects should avoid taking tobacco products, alcohol and other foods or drinks that might affect drug metabolism (such as coffee, tea, cola or other caffeinated drinks);
- The blood pregnancy test of female subjects at baseline period is negative.
Exclusion
- Participants with disease history of uterine bleeding, uterine ovarian tumor, pituitary tumor, or other diseases evaluated by the principal investigator as not suitable for this study;
- Have a history of migraine within 3 months before screening;
- Participants with clinically significant diseases (such as neuropsychiatric system, cardiovascular system, urinary system, digestive system, respiratory system, skeletal muscle system, endocrine and metabolic system, blood system, skin disease, immune system, tumor, etc.) were evaluated by the researcher as not suitable for this study;
- Within 2 weeks before screening, participants have suffered from VMS that inducing the interrupt of daily activities;
- Within 30 days before taking drug, participants have taken hormonal treatment or other therapy due to VMS;
- Within 4 weeks or 5 half-lives (whichever is longer) before screening, and during the whole study period, it is expected to take any medicine and health care products, including prescription drugs, immunomodulator or Chinese herbal medicine, etc.;
- Within 3 months before screening, participants have taken hormonal contraceptive;
- Participants have participated in any clinical study or taken study drugs within 3 months before screening;
Key Trial Info
Start Date :
November 12 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2024
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06122181
Start Date
November 12 2023
End Date
September 30 2024
Last Update
March 13 2024
Active Locations (1)
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1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100000