Status:
RECRUITING
Testing the Interplay of Gambling, Emotion and Reward
Lead Sponsor:
Hôpital le Vinatier
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Gambling Addiction
Eligibility:
All Genders
18-65 years
Brief Summary
Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account...
Detailed Description
Background Gambling addiction has often been conceptualized as the result of reward processing dysfunction in the brain, particularly in the striatum, a key structure of the reward system. Although a ...
Eligibility Criteria
Inclusion
- For all participants (gamblers and healthy subjects)
- Aged between 18 and 65
- Fluent French, read and spoken
- Male and Female
- Informed consent to take part in the research
- For gamblers :
- Number of DSM-5 critera for gambling disorder ≥3
- Score ≥ 5 on the Problem Gambling Severity Index questionnaire (PGSI)
- Have a smartphone
- For healthy subjects :
- no DSM-5 criteria for gambling addiction
- Score ≤ 2 on the Problem Gambling Severity Index questionnaire (PGSI)
Exclusion
- For all participants (gamblers and healthy subjects):
- Contra-indication to MRI
- Protected Adults
- Breast feeding or pregnant women
- Neurological disorder or severe chronic illness (diabetes, heart disease, kidney disease, lung disease or liver disease, inflammatory disease….)
- Pharmacological treatment with psychotropic action (\>1 time / week)
- Regular drug use (\> 1 time/ week for at least 3 months in the last 6 months)
- Positive urine drug test on the day of the MRI sessions
- For gamblers:
- Psychiatric treatment \> 1 month (pharmacological or CBT)
- Other DSM-5 diagnosis : schizophrenia, bipolar disorder, ADHD, autism, current PTSD, eating disorders, current major depressive episode, anxiety disorder, substance use disorder except nicotine, obsessive compulsive disorder.
- For healthy subjects :
- \- Any DSM-5 diagnosis except nicotine addiction
Key Trial Info
Start Date :
March 27 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 20 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06122298
Start Date
March 27 2024
End Date
May 20 2028
Last Update
July 17 2025
Active Locations (1)
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1
CH le Vinatier
Bron, France, 69678