Status:
NOT_YET_RECRUITING
Preemptive TIPS for Variceal Bleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis
Lead Sponsor:
West China Hospital
Collaborating Sponsors:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Beijing YouAn Hospital
Conditions:
Portal Hypertension
Portal Vein Thrombosis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Portal vein thrombosis (PVT) can lead to a further increase in portal venous pressure and increase the risk of rebleeding. Whether patients with acute esophagogastric variceal bleeding with occlusive ...
Detailed Description
Portal vein thrombosis (PVT) is a common complication in patients with cirrhosis, and the cumulative incidence of PVT is 4.6%, 8.2%, and 10.7% at 1 year, 3 years, and 5 years, respectively. PVT can le...
Eligibility Criteria
Inclusion
- Cirrhosis (diagnosed by imaging, laboratory tests, clinical symptoms, or liver biopsy);
- Admission due to acute bleeding from esophagogastric varices;
- Thrombus in the main trunk of the portal vein occupying ≥50% of the lumen.
Exclusion
- Prior treatment with TIPS or surgical shunt;
- Presence of contraindications to endoscopic treatment, carvedilol, or TIPS;
- Presence of hepatocellular carcinoma exceeding Milan criteria;
- Presence of other systemic malignant tumors with expected survival time not exceeding 6 months;
- Presence of uncontrollable infection or sepsis;
- Presence of cardiac, pulmonary, or renal failure;
- Pregnant or lactating women;
- Refusal to sign the informed consent form.
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06122753
Start Date
January 1 2024
End Date
December 1 2026
Last Update
November 8 2023
Active Locations (1)
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1
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610000