Status:
RECRUITING
Androgens and NAFLD Longitudinal Cohort Study
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Duke University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
PCOS
NAFLD
Eligibility:
FEMALE
18-42 years
Brief Summary
The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can caus...
Detailed Description
The studies central hypothesis is that androgens promote liver injury and NAFLD/NASH progression in PCOS, which occurs through aberrant lipid activity (including lipotoxicity and dysregulated de novo ...
Eligibility Criteria
Inclusion
- Metabolic associated steatohepatitis (MASH) (formerly NASH)
- PCOS
- Non-PCOS
Exclusion
- High levels of alcohol use (more than 7 drinks a week)
- Current pregnancy
- Other causes of hepatic steatosis
- Weight loss of more than 10% body weight in the last 6 months
Key Trial Info
Start Date :
January 22 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06124261
Start Date
January 22 2024
End Date
December 1 2028
Last Update
March 21 2025
Active Locations (2)
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1
University of California San Francisco
San Francisco, California, United States, 94143
2
Duke University
Durham, North Carolina, United States, 27708