Status:
RECRUITING
An Investigator-initiated Linked Study to OCEANIC-AF
Lead Sponsor:
East and North Hertfordshire NHS Trust
Collaborating Sponsors:
Liverpool Heart and Chest Hospital NHS Foundation Trust
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Brief Summary
Impaired endogenous fibrinolysis is a recently recognised risk factor for thrombotic events in patients with cardiovascular disease. Enhancing endogenous fibrinolysis in such individuals represents a ...
Detailed Description
The risk of a clot forming in a blood vessel, which can cause a heart attack or stroke, is determined partly by how "sticky" the blood is and partly by the effectiveness of the natural defences in the...
Eligibility Criteria
Inclusion
- Patients aged 18 years or over
- Patients enrolled in OCEANIC-AF study
- Free from the exclusion criteria below
- The patient is willing and able to understand the Patient Information Sheet and provide written informed consent
- The patient agrees to comply with the drawing of blood samples for the assessments.
Exclusion
- Inability to provide valid informed consent
- Patients aged \< 18 years of age
- Patients with significant neurological, hepatic, renal, endocrine, gastrointestinal, pulmonary, haemorrhagic, metabolic or other disease likely to confound the study requirements or analyses
- Patients with a history of substance abuse or signs or clinical features of active substance abuse or psychiatric disease
- Alcohol consumption above 21 units per week
- Any illness deemed significant by the investigator during the four (4) weeks preceding the screening period of the study
- Any major bleeding diathesis or blood dyscrasia (platelets \<70 x 109/l, Hb \<80 g/dl, INR \>1.4, APTT \>x 2 UNL, leucocyte count \<3.5 x 109/l, neutrophil count \<1 x 109/l)
Key Trial Info
Start Date :
November 3 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 17 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06124612
Start Date
November 3 2023
End Date
September 17 2026
Last Update
November 9 2023
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom
2
East and North Herts NHS Trust
Stevenage, United Kingdom