Status:
UNKNOWN
Trajectory Analysis of NLR and Its Association With Efficacy of Immunochemotherapy in ESCC.
Lead Sponsor:
Guangdong Provincial People's Hospital
Conditions:
Esophageal Squamous Cell Carcinoma
Immunotherapy
Eligibility:
All Genders
Brief Summary
Conduct a retrospective and prospective study to confirm the association between blood cells counts and the efficacy and safety in immunochemotherapy in patients with advanced esophageal cancer.
Detailed Description
Studies have already demonstrated the feasibility of prognostic role of protein biomarkers change during the treatment trajectory of patients in several carcinoma,However, no study focused on the valu...
Eligibility Criteria
Inclusion
- Pathologically confirmed esophageal squamous cell carcinoma
- Potentially resectable esophageal squamous cell carcinoma at first diagnosis (cT1-4a N1-2 M0, cT3-T4a N0M0)
- Treatment-naive
- Expected life span \> 6 months
- Aged 18 - 75 years old
- Adequate organ functions
- Performance Status (PS) 0-2
- Participants are fully informed about the whole study and are willing to sign the informed consent
Exclusion
- Previous history of thoracic surgery or radiation
- Cervical or multi-origin esophageal cancer
- Known or suspected experimental drug allergy
- Pregnant or lactating women
- Esophagomediastinal fistula
- Peripheral neuropathy
- Previous cancer history other than esophageal cancer
- Severe organ function deterioration that can not tolerate neoadjuvant therapy
- Previous autoimmune diseases
- diabetic history \> 10 years
- interstitial pulmonary disease, non-infectious pulmonitis
- Active type B hepatitis
- Any other conditions that may affect patients' safety and compliance
Key Trial Info
Start Date :
November 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06125262
Start Date
November 1 2022
End Date
July 31 2025
Last Update
December 28 2023
Active Locations (1)
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1
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China, 510080