Status:
UNKNOWN
Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients.
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Conditions:
Knee Osteoarthritis
Metformin
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
The goal of this randomized, double blind, placebo-controlled clinical trial is to learn about, the effect of metformin compared with placebo-controlled group on disease activity and interleukin-6 lev...
Detailed Description
Osteoarthritis (OA) is a worldwide highly prevalent chronic joint disease commonly affecting individuals of 40 years and older. OA is highly debilitating, encompassing various physical symptoms like p...
Eligibility Criteria
Inclusion
- Patients with knee pain
- Radiographic evidence of knee osteoarthritis (Grade II-III)
- Age 18-65 years
- Both male and female
- Normal BMI(for asians): 18.5-22.9 kg/m2
Exclusion
- Diagnosed case of Diabetes Mellitus, renal, hepatic, cardiovascular or pulmonary disease
- Diagnosed case of Gout or pseudogout
- Diagnosed case of systemic inflammatory conditions such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease
- Patients currently receiving immunosuppressant, carbonic anhydrase inhibitors(topiramate), ranolazine, vandetanib, dolutegravir
- History of receiving a corticosteroid injection in the last three months
- Prior history of knee trauma or surgery
- Metformin use or history of use in the last two months
- Known allergy to metformin
- History of lactic acidosis
- Patient with habit of excessive alcohol intake
- Pregnancy
- Patients unwilling to participate or unwilling to give written consent
- Participation in another clinical trial
Key Trial Info
Start Date :
October 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2024
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT06126029
Start Date
October 15 2023
End Date
June 30 2024
Last Update
November 14 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh, 1000