Status:
COMPLETED
Childhood Adversity, Inflammatory Reactivity and Persistent Pain
Lead Sponsor:
University of Cape Town
Conditions:
Chronic Pain
Central Sensitisation
Eligibility:
All Genders
18-65 years
Brief Summary
The goal of this observational study is to investigate how adverse experiences during childhood are linked to people experiencing persistent pain and fatigue in adulthood. The questions the investiga...
Detailed Description
Background Adverse experiences during childhood (childhood adversity) are associated with an increased risk of persistent pain and fatigue in adulthood. While the physiological relationships that lin...
Eligibility Criteria
Inclusion
- Between the ages of 18 and 65 years old.
Exclusion
- Incompetence to consent and participate, e.g. acute psychosis or high suicide risk.
- Pregnancy,
- Electrical implants (e.g. pace-maker),
- Metal implants in the forearm,
- Tattoos on the forearm,
- Any visible injury or open wounds in the forearm,
- Known history of allergic reactions to vaccines,
- Has received the current season's influenza vaccine,
- Chronic pain (pain on most days for the past 3 months),
- Diabetes Mellitus,
- Peripheral vascular disease,
- Sensory impairment in the forearm, shoulder and lower back,
- Use of medication that could later skin sensitivity (e.g. analgesic medication, immune modulators, topical medical creams),
- Cardiovascular disorders,
- Medication that alters immune function (e.g. NSAIDs, steroids),
- Smoking habit,
- Febrile illness in the preceding 4 weeks.
Key Trial Info
Start Date :
June 21 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 20 2023
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT06127693
Start Date
June 21 2022
End Date
September 20 2023
Last Update
November 13 2023
Active Locations (1)
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1
University of Cape Town
Cape Town, Western Cape, South Africa, 7701