Status:
COMPLETED
Application of Perioperative Remote Ischemic Conditioning in Patients Undergoing Hepatectomy
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Conditions:
Hepatic Hemangioma
Liver Cancer
Eligibility:
All Genders
25-75 years
Phase:
NA
Brief Summary
Our primary aim is to investigate whether perioperative remote ischemic conditioning (PRIC) as an adjunctive treatment can improve postoperative recovery in patients undergoing hepatectomy as an adjun...
Detailed Description
Remote Ischemic Conditioning (RIC) can be applied as repeated short-lasting ischemia in a distant tissue that results in protection against subsequent long-lasting ischemic injury in the target organ....
Eligibility Criteria
Inclusion
- Patients undergoing hepatectomy under general anesthesia
- American Society of Anesthesiology (ASA) grade of II \~ III
- Male and female patients, age 25 to 75 years
- New York Heart Association (NYHA) grade of I \~ III
Exclusion
- Patients with limb deformity or peripheral vascular disease affecting upper limb function
- Patients with a medical history of nervous system, immune system and mental illness
- Patients who have received hepatectomy in the past, have important organ diseases or have undergone surgical treatment recently
- Patients who have recently used anti-inflammatory analgesics, anticoagulants, hormone drugs, immunosuppressants, and ATP-sensitive K-channel blockers (KATP)
- Preoperative severe renal insufficiency (serum creatinine \> 442 umol/L, with or without serum potassium \> 6.5 mmol/L, or the clinician-recognized need for renal replacement therapy), liver insufficiency (Child-Pugh grade C)
- Patients and/or their family members refuse to participate in the program
Key Trial Info
Start Date :
November 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 9 2024
Estimated Enrollment :
135 Patients enrolled
Trial Details
Trial ID
NCT06130436
Start Date
November 2 2023
End Date
August 9 2024
Last Update
August 19 2024
Active Locations (1)
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1
The Second Affiliated Hospital, Chongqing Medical University
Chongqing, China