Status:
RECRUITING
Characterisation of TLR4+ Blood Cells in Patients With Solid Cancer
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
All Types of Solid Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The potential of immunotherapy in the treatment of cancer is now well documented. While excessive activation of the immune system may be associated with severe reactions and/or auto-immune syndromes, ...
Eligibility Criteria
Inclusion
- Patient older than 18 years
- Patient who gave its written informed consent to participate to the study
- Patient with histologically confirmed diagnosis of any type of malignancy (solid tumors)
- Patient with a minimum of 6 months life expectation at inclusion
- Patient covered by a medical insurance
- Inclusion criteria specific to cohort 1:
- \- Patient with metastatic disease or unresectable locally advanced malignancy (solid tumors) who is naive of immune checkpoint inhibitors (ICI)-based immunotherapy and is due to initiate an ICI immunotherapy alone or in combination with any other systemic anticancer treatment.
- Inclusion criteria specific to cohort 2:
- \- Patient with a diagnosed malignancy amenable to surgery with curative intent who is naive of any anticancer treatment
Exclusion
- Patient with secondary malignancy unless this malignancy is cured with no evidence of recurrence for at least 5 years.
- Pregnant or breastfeeding woman or expecting to conceive
- Patient who is deprived of liberty due to judicial or administrative decision
- Patient with known psychiatric disorders that would interfere with cooperation with the requirements of the trial
- Patient admitted in a social or sanitary institution for an objective other than the one of this trial
- Adult patient under legal protection
Key Trial Info
Start Date :
May 29 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06131775
Start Date
May 29 2024
End Date
May 1 2028
Last Update
May 18 2025
Active Locations (4)
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1
Pneumology Unit
Bron, France, 69500
2
Dermatology Unit
Pierre-Bénite, France, 69495
3
Oncological and Gynecological Surgery Unit,
Pierre-Bénite, France, 69495
4
Oncology Unit, Hospices Civils de Lyon Sud
Pierre-Bénite, France, 69495