Status:
RECRUITING
Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Parkinson Disease
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This study aims to determine the effects of aerobic exercise as a primer to add-on virtual reality (VR)-based rehabilitation on balance, postural control and neuroplasticity (ability of brain to adapt...
Detailed Description
This study will enroll individuals diagnosed with Parkinson's disease who will be randomly assigned to 2 groups: 1) high intensity endurance exercise and virtual reality (experimental) or 2) stretchin...
Eligibility Criteria
Inclusion
- Diagnosis of idiopathic PD (ages 18 -85) in Hoehn and Yahr stages 2 - 3.
- Subjects need to demonstrate a score of equal to or greater than 23 on the Mini Mental State Examination.
- Subjects who have a score of ≤21.5 on the Mini Balance Evaluations Systems Test (miniBESTest).
Exclusion
- Subjects with a history of other neurological diseases (i.e., stroke, multiple sclerosis).
- Subjects with a history of severe cardiopulmonary disease, uncontrolled hypertension, orthostatic hypotension, uncontrolled diabetes, severe osteoporosis, severe arthritis affecting their lower extremity joints.
- Subjects with a history of PD-specific surgical procedures such as deep brain stimulation etc.
- Subjects with a history of head injury.
- Subjects with a history of seizures or epilepsy.
- Subjects who are currently pregnant.
- Individuals who use of medications that could alter corticomotor excitability or increase risk of seizure.
- Individuals with skull abnormalities, fractures or unexplained, recurring headaches.
Key Trial Info
Start Date :
February 9 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06133283
Start Date
February 9 2024
End Date
December 31 2025
Last Update
May 21 2025
Active Locations (1)
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1
UT Health San Antonio- Dept. of Physical Therapy
San Antonio, Texas, United States, 78229