Status:
NOT_YET_RECRUITING
Conditioning Regimen Containing Melphalan and Cladribine for Refractory / Relapsed AML
Lead Sponsor:
Institute of Hematology & Blood Diseases Hospital, China
Conditions:
Acute Myeloid Leukemia
Eligibility:
All Genders
Up to 60 years
Phase:
PHASE2
Brief Summary
This project is a prospective, multicenter, randomized controlled clinical study. The subjects were refractory / relapsed AML patients aged ≤ 60 years diagnosed by bone marrow cell morphology, immunol...
Eligibility Criteria
Inclusion
- Refractory / relapsed AML.
- Patients with a HLA matched related or unrelated donor (9\~10/10) or haplo-identical related donor, plan to receive HSCT.
- Age ≤ 60 years old, men and women are not limited.
- The Eastern Oncology Collaborative Group Physical Status Assessment ( ECOG-PS ) was 0-2 points.
- Informed consent must be signed before the start of the study procedure. Informed consent must be signed by the patient or his or her immediate family members who are 18 years of age or older ; informed consent was signed by the legal guardian for children and adolescent patients under 18 years old. Considering the patient 's condition, if the patient 's signature is not conducive to the treatment of the disease, the informed consent is signed by the legal guardian or the patient 's immediate family.
Exclusion
- Have a history of cancer and have received any treatment for this tumor in the past 3 years. But remove superficial bladder cancer, skin basal cells or squamous cell carcinoma, cervical epithelium. Intraepithelial neoplasia ( CIN ) or prostatic intraepithelial neoplasia ( PIN ).
- MPAL.
- It is known that the serological reaction of HIV or active hepatitis C virus is positive.
- The inability to cooperate with the requirements of research, treatment and monitoring due to mental illness or other conditions.
- Pregnant patients or patients who could not take appropriate contraceptive measures during treatment.
- Previously received hematopoietic stem cell transplantation.
- Active heart disease, defined as one or more of the following :
- ) Uncontrolled or symptomatic angina history.
- ) Myocardial infarction less than 6 months away from the study.
- ) Have a history of arrhythmia requiring drug treatment or severe clinical symptoms.
- ) Uncontrolled or symptomatic congestive heart failure ( \> NYHA class 2 ).
- ) The ejection fraction is lower than the lower limit of the normal range.
- Researchers evaluated that is not suitable for the group.
Key Trial Info
Start Date :
November 24 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 20 2028
Estimated Enrollment :
237 Patients enrolled
Trial Details
Trial ID
NCT06133556
Start Date
November 24 2023
End Date
October 20 2028
Last Update
November 15 2023
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