Status:
RECRUITING
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
Lead Sponsor:
Beth Israel Deaconess Medical Center
Conditions:
Perioperative/Postoperative Complications
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
60+ years
Brief Summary
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in pa...
Detailed Description
Study Procedures: Pre-operative: 1. Assessment by an anesthesiologist, and brief patient education about cerebral autoregulation and post-operative delirium. 2. MOCA baseline cognitive assessment by...
Eligibility Criteria
Inclusion
- Age ≥ 60 years
- Undergoing any non-cardiac surgeries including but not limited to vascular, hepatobiliary, or complex spine surgeries requiring general anesthesia with arterial catheterization for monitoring
Exclusion
- Non-English speaking (Justification: cognitive assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)
- Cognitive impairment as defined by total MoCA score \< 10 (justification: baseline cognitive dysfunction will confound primary outcome measure)
- Significant visual impairment (justification: will be difficult for patients to draw individual components in MOCA score)
- Emergent surgery (justification: insufficient time to initiate intervention)
- History of stroke within the last 3 months (justification: cognitive dysfunction secondary to stroke can confound outcome measures
Key Trial Info
Start Date :
April 17 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06133842
Start Date
April 17 2024
End Date
July 1 2027
Last Update
October 28 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215