Status:
TERMINATED
Accelerated rTMS for Psychomotor Slowing
Lead Sponsor:
University of Bern
Conditions:
Schizophrenia; Psychosis
Schizophrenia and Related Disorders
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to optimize the treatment of psychomotor slowing in patients with schizophrenia using Transcranial Magnetic Stimulation (TMS). A previous randomized controlled trial...
Detailed Description
Schizophrenia is a chronic disorder causing tremendous burden to the patients, families, and society. Besides prominent symptoms such as hallucinations, delusions, and thought disorder, the majority o...
Eligibility Criteria
Inclusion
- 18-60 years.
- Ability and willingness to participate in the study
- Ability to provide written informed consent
- Informed Consent as documented by signature (Appendix Informed Consent Form)
- Schizophrenia spectrum disorders according to DSM-5 with psychomotor slowing (SRRS score ≥ 15).
Exclusion
- Substance abuse or dependence other than nicotine.
- Past or current medical or neurological conditions associated with impaired or aberrant movement, such as brain tumors, stroke, M. Parkinson, M. Huntington, dystonia.
- Severe head trauma with subsequent loss of consciousness.
- Epilepsy or other convulsions.
- History of any hearing problems or ringing in the ears.
- Standard exclusion criteria for TMS (implanted electronic devices (e.g. pacemakers, implantable cardioverter-defibrillators, vagus nerve stimulators and wearable cardioverter-defibrillators, ocular implants, deep brain stimulators, implanted medication pumps, intracardiac lines even when removed) and/or conductive objects near the coil (e.g. cochlear implants, implanted electrodes/stimulators, aneurysm clips or coils, stents and bullet fragments)
- Women who are pregnant or breastfeeding.
- Any TMS treatment in the past 2 months.
- If applicable: standard exclusion criteria for MRI (study participation without MRI is possible)
- Intention to become pregnant during the course of the study
- Previous enrolment into the current study
- Enrolment of the investigator, his/her family members, employees, and other dependent persons
Key Trial Info
Start Date :
September 22 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2024
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT06134661
Start Date
September 22 2023
End Date
August 30 2024
Last Update
September 25 2024
Active Locations (1)
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1
University Hospital of Psychiatry and Psychotherapy
Bern, Switzerland, 3000