Status:
COMPLETED
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression
Lead Sponsor:
Al-Azhar University
Conditions:
Periodontitis
Gingivitis
Eligibility:
All Genders
18+ years
Brief Summary
T Regulatory cells which suppressor subset of T cells and related cytokines remain in blood and infiltrates into the tissue under need. The role of Treg and related cytokines in succession of periodon...
Detailed Description
T regs infiltration might reveal a trial to control tissue damage, however it also might be suggestive of a destructive effect of Tregs in periodontitis . Tregs can actually play a damaging role as th...
Eligibility Criteria
Inclusion
- periodontally healthy persons without any signs of periodontal disease. This was determined by the absence of attachment loss and bleeding upon probing either ˂ 10% or probing depth ˂3 mm.
- persons exhibiting generalized chronic gingivitis exhibiting signs of erythema, bleeding on probing up to 20%, edema, probing pocket depth less than 3 mm and no periodontal attachment loss.
- persons having severe generalized form of chronic periodontitis exhibiting PPD ≥ 6 mm, CAL ≥ 5mm and bone loss affecting at least six teeth as observed in dental periapical radiograph.
Exclusion
- Patients with systemic diseases according to Modified Cornell Medical Index criteria
- Patients receiving either antibiotics or non-steroidal anti- inflammatory at least 3 months prior to samples collection.
- Patients subjected to previous periodontal therapy 6 months before sampling.
- Patients with systemic or local inflammatory conditions other than periodontal disease.
- The smokers.
- Neither lactating nor pregnant.
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06135116
Start Date
November 1 2023
End Date
January 1 2024
Last Update
January 30 2024
Active Locations (1)
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1
Department of oral medicine, Periodontology, Oral diagnosis and dental radiology Faculty of dental medicine
Asyut, Asyut Governorate, Egypt, 71111