Status:
UNKNOWN
Spinal Cord Gray Matter Imaging in Spinal Muscular Atrophy
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Spinal Muscular Atrophy Type III
Spinal Muscular Atrophy Type II
Eligibility:
All Genders
11+ years
Brief Summary
This study aims to measure the spinal cord gray matter in patients with spinal muscular atrophy (SMA) type II and III in comparison with age- and sex-matched healthy controls (HC) using rAMIRA (radial...
Detailed Description
Patients with the diagnosis of 5q-SMA (spinal muscular atrophy) types II or III (confirmed by genetic testing) will be recruited. Healthy age and sex-matched controls will also be investigated. Patie...
Eligibility Criteria
Inclusion
- Inclusion Criteria (patients)
- 11 years or older
- Informed consent by the participants or, in children below the age of legal consent, by a legally authorized representative
- genetically confirmed diagnosis of 5q-SMA (Types II or III)
- Exclusion Criteria (patients):
- active other neurological or neuromuscular condition explaining the symptoms or a significant part of it
- other neurological or neuromuscular conditions interfering with the examinations
- other severe chronic disease
- pregnancy
- general contraindications against MRI scanning (e.g. pacemakers)
- not able to understand the patient information due to language barriers
- In the event of a participant incapable of judgment, symptoms showing that the participant is unwilling to participate in the study will result in the participant being excluded from participation
- Inclusion Criteria (healthy volunteers)
- participants will be selected to be age-and sex-matched to the patients
- 11 years or older
- Informed consent by the participants or, in children below the age of legal consent, by a legally authorized representative
- Exclusion Criteria (healthy volunteers):
- active neurological or neuromuscular condition
- other neurological or neuromuscular conditions interfering with the examinations
- other severe chronic disease
- pregnancy
- general contraindications against MRI scanning (e.g. pacemakers)
- not able to understand the patient information due to language barriers
- In the event of a participant incapable of judgment, symptoms showing that the participant is unwilling to participate in the study will result in the participant being excluded from participation
Exclusion
Key Trial Info
Start Date :
August 17 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 15 2025
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT06137612
Start Date
August 17 2020
End Date
September 15 2025
Last Update
November 18 2023
Active Locations (1)
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1
University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031