Status:
RECRUITING
Identifying Networks Underlying Compulsivity in Anorexia Nervosa for Targeting With Neuromodulation
Lead Sponsor:
University of California, San Francisco
Conditions:
Anorexia Nervosa
Eligibility:
All Genders
16-75 years
Phase:
NA
Brief Summary
Transcranial Magnetic Stimulation (TMS) is approved by the Food and Drug Administration (FDA) for the treatment of refractory Major Depressive Disorder (MDD) and obsessive-compulsive disorder (OCD). A...
Detailed Description
To determine if accelerated theta burst rTMS can treat symptoms of AN and normalize abnormal network connectivity, the investigators will enroll 20 patients with AN (aged 16-45) to receive five treatm...
Eligibility Criteria
Inclusion
- outpatients
- ages 16 - 75 for Aim 2
- meets Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for AN
- stable on chronic psychotropic medications for 4 weeks prior to the study and agreeable to continue throughout the study
- participants may continue to take medications and record daily usage throughout the study
- capacity to provide informed consent
- ability to tolerate clinical study procedures
- successfully complete the screening forms without any contraindications
Exclusion
- Psychiatric: schizophrenia, bipolar disorder, prior psychosurgery, prior electroconvulsive therapy (ECT)
- Neurologic: severe neurocognitive disorder, seizure disorder, certain structural brain lesions (e.g., intracranial mass lesions, hydrocephalus, sequelae of meningitis)
- TMS contraindications: implanted device; presence of metal in the head, including eyes and ears (excluding dental implants); certain tics; medications or systemic illness that predispose seizure risk
- Subjects with an unstable physical, systemic, or metabolic disorder (e.g., unstable hypertension)
- Females who are pregnant or nursing
- Inability to complete the research study
Key Trial Info
Start Date :
October 16 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06138782
Start Date
October 16 2023
End Date
September 1 2025
Last Update
June 8 2025
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94107