Status:
RECRUITING
Liver Transplantation in Intrahepatic Cholangiocarcinoma
Lead Sponsor:
Rutgers, The State University of New Jersey
Conditions:
Intrahepatic Cholangiocarcinoma
Cholangiocarcinoma, Intrahepatic
Eligibility:
All Genders
18-89 years
Brief Summary
The aim of the current study is to determine the potential efficacy of liver transplantation in the form of patients' overall survival (OS) after neoadjuvant systemic therapy in patients with biologic...
Detailed Description
Research Significance: Cholangiocarcinoma, which arises from biliary epithelium, can be anatomically subdivided into distal, hilar, and intrahepatic subgroups. Intrahepatic cholangiocarcinoma (iCCA) ...
Eligibility Criteria
Inclusion
- Age ≥18 years of age on the day of consenting to the study.
- Patients must have histologically confirmed diagnosis of locally advanced intrahepatic cholangiocarcinoma
- Confirmed diagnosis of locally advanced unresectable iCCA with no vascular invasion, lymph node, or extrahepatic disease.
- Unresectable disease based on tumor location or underlying liver disease
- Patients must have ≥ 6 months of disease stability or tumor regression on neoadjuvant therapy. In cases in which patients had received second-line therapy, disease must also have been controlled for ≥ 6 months on that regimen.
- Patients who had previous surgical resection for iCCA are eligible if surgery occurred more than 6 months prior to listing, and patients have had ≥ 6 months of disease stability or response on therapy.
- ECOG performance status ≤1 (Karnofsky ≥70%, see Appendix A).
- Patients must have organ and marrow function acceptable for liver transplantation per institutional protocol:
- If history of chronic hepatitis B virus (HBV) infection, viral load should be undetectable on suppressive therapy.
- If history of chronic hepatitis C virus (HCV) infection, patients should have undetectable HCV viral load.
- Women of child-bearing years must have contraception plan in place from the time of study enrollment until at least one year following liver transplant.
- Ability to understand and the willingness to sign a written informed consent document
- Meets all other medical and psychosocial criteria for liver transplant
- Demonstrate ability to comply with study procedures
Exclusion
- Age \<18 years of age on the day of consenting to the study.
- Patients who have extrahepatic metastases, lymph node involvement, invasion or encasement of major hepatic vascular structures, perforation of the visceral peritoneum, invasion of extrahepatic structures, invasion of perihilar fat, periductular invasion, concurrent hepatoma or mixed hepatocellular cholangiocarcinoma.
- Concurrent severe and/or uncontrolled concurrent illness including, but not limited to, ongoing or active infection, acute fulminant liver failure, symptomatic congestive heart failure, unstable angina pectoris, severe uncorrected coronary artery disease, severe cerebrovascular disease, severe pulmonary disease, or psychiatric illness/social situations that would limit compliance with study requirements and that would exclude the patient from eligibility for liver transplantation per institutional protocol.
- Prior solid organ or bone marrow transplant
- Dependent on ≥2 IV inotropic support to maintain hemodynamics
- Previous (within the past 5 years) or concurrent presence of other cancer, except non-melanoma skin cancer and in situ carcinomas.
- Eastern Cooperative Oncology Group (ECOG) Performance Status Scale score \>1 (Karnofsky \<70%, see Appendix A).
- Unable to understand and sign a written informed consent document
- Untreated viral hepatitis
- Pregnant or breast-feeding women
- HIV-infected patients
Key Trial Info
Start Date :
December 15 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2029
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06140134
Start Date
December 15 2023
End Date
November 1 2029
Last Update
March 12 2024
Active Locations (2)
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1
Rutgers New Jersey Medical School
Newark, New Jersey, United States, 07103
2
University Hospital
Newark, New Jersey, United States, 07103