Status:
RECRUITING
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
Lead Sponsor:
Region Skane
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.
Eligibility Criteria
Inclusion
- Adult (≥ 18 years of age)
- Septic shock according to the Sepsis 3 criteria at any time within 12 hours after ICU admission (suspected or confirmed infection, plasma lactate above 2 mmol/L, and infusion of vasopressor/inotrope to maintain mean arterial pressure of 65mmHg or above after receiving adequate fluid resuscitation \[\> 1L within 12 h of screening\]) and need for vasopressors at the time of screening.
Exclusion
- Confirmed or suspected pregnancy
- Previous inclusion in the trial
- Screened more than 12 hours after ICU admission
Key Trial Info
Start Date :
November 27 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
1850 Patients enrolled
Trial Details
Trial ID
NCT06140147
Start Date
November 27 2023
End Date
July 1 2028
Last Update
December 16 2025
Active Locations (20)
Enter a location and click search to find clinical trials sorted by distance.
1
Helsinki University Hospital
Helsinki, Finland
2
Tampere University Hospital
Tampere, Finland
3
Danderyd Hospital
Danderyd, Sweden
4
Malar Hospital
Eskilstuna, Sweden