Status:
COMPLETED
Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery
Lead Sponsor:
Department of Medical Services Ministry of Public Health of Thailand
Conditions:
Preemptive Analgesia
Gynecological Surgery
Eligibility:
FEMALE
18-70 years
Phase:
PHASE4
Brief Summary
The research is to test the preemptive analgesic efficacy of Parecoxib drug in gynecological surgery by comparing Parecoxib drug and NSS administration 15 min before starting the surgery which the res...
Detailed Description
The research is working on testing the preemptive analgesic efficacy of Parecoxib drug in gynecological surgery whether its can reduce postoperative pain score, reduce total opioid consumption in firs...
Eligibility Criteria
Inclusion
- Female patients age between 18-70 year-old, who participate in explor lap gynecological surgery (Hysterectomy, Adnexal surgery and surgical stagings) using general anesthesia technique
- American society of Anesthesiologists physical status grade I-II
- Capable to communicate in Thai language
Exclusion
- Allergic to NSAIDs and opioid
- Allergic to Parecoxib drug
- Underlying neuropathic pain
- Pregnant woman or woman who undergoes breast feeding
- Uncontrolled hypertension disease, BP \>160/110 at admission date
- Underlying ischemic heart disease, Ischemic stroke or peripheral arterial disease
- History status post coronary artery bypass grafting
- Patients who take Aspirin within 7 days before surgery date
- Had underlying which is contraindiated to NSAIDs drug such as Gastritis, history of GI ulcer, chronic kidney disease (Cr clearance \< 30ml/min), liver cirrhosis (Child-Pugh class B or above/ serum albumin \< 25 g/l)
- Patients who had NSAIDs drug while admit in hospital for preparing the operation before surgery date
Key Trial Info
Start Date :
September 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 27 2024
Estimated Enrollment :
178 Patients enrolled
Trial Details
Trial ID
NCT06140238
Start Date
September 10 2023
End Date
June 27 2024
Last Update
November 14 2024
Active Locations (1)
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1
Rajavithi Hospital
Bangkok, Thailand