Status:
NOT_YET_RECRUITING
Brain Blood Flow Responses at Rest and During Exercise
Lead Sponsor:
University of British Columbia
Conditions:
Cerebrovascular Regulation
Eligibility:
All Genders
7-35 years
Brief Summary
Tight regulation of brain blood flow is integral for delivery of oxygen and energy for survival. During childhood, the brain has a twofold higher metabolic requirement, thus requires greater blood flo...
Detailed Description
The goal of this cross-sectional experimental study to determine the influence age, sex and pubertal status on cerebrovascular responses at rest and during isometric exercise. The main objective is t...
Eligibility Criteria
Inclusion
- Are aged between 7-10 years, 12-16 years or 19-35 years
- Male or Female
- Have a normal blood pressure (\<160/110 mmHg) and are not taking any anti-hypertensive medications.
- No prior or current history of cardiorespiratory of cerebrovascular diseases.
- Can communicate in English
Exclusion
- Inability to perform handgrip exercise
- Are currently taking any medications known to influence vascular function, heart rate or blood pressure
- Have epilepsy
- Are a current smoker
- Have known cardiometabolic abnormalities
- Have congenital cardiac abnormalities (e.g., tetralogy of Fallot)
- Unstable angina (frequent chest pain)
- Atrial Fibrillation
- Myocardial infarction (heart attack) within the previous 3 months
- Transient ischemic attack (TIA) within the previous 6 months
- Heart failure ≥ class 2
- Have a known respiratory disease (e.g., asthma)
- Have a known metabolic disease (e.g., Type 1 diabetes)
- Are unable to exercise
- Are pregnant
- Less than 6 months post childbirth or stopped breastfeeding within the last month
Key Trial Info
Start Date :
May 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06142045
Start Date
May 1 2024
End Date
January 1 2025
Last Update
March 6 2024
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