Status:
UNKNOWN
Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT
Lead Sponsor:
The First Affiliated Hospital of Soochow University
Conditions:
Graft Vs Host Disease
Eligibility:
All Genders
Brief Summary
This research project delves into the critical role of gut immunity in the occurrence and progression of acute graft-versus-host disease (aGVHD) post allogeneic hematopoietic stem cell transplantation...
Detailed Description
The intestinal immune system plays a pivotal role in the onset, progression, and evolution of acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation (allo...
Eligibility Criteria
Inclusion
- Patients with hematologic disorders undergoing allo-HSCT.
Exclusion
- Patients with confirmed pathogenic intestinal infections and severe systemic infections at the time of sampling.
- Diagnosis of autoimmune diseases, metabolic disorders, and chronic gastrointestinal diseases.
- Pre-transplant diseases not in complete remission.
- Post-transplant hematopoietic engraftment failure or pre-engraftment mortality.
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06143501
Start Date
September 1 2020
End Date
December 31 2024
Last Update
November 22 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215000