Status:
WITHDRAWN
A Pilot Study For Patients Receiving Radiation Therapy for Liver Cancer
Lead Sponsor:
Montefiore Medical Center
Collaborating Sponsors:
HepQuant, LLC
Perspectum
Conditions:
Cancer, Hepatocellular
Radiotherapy Side Effect
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the role of quantitative MR imaging and blood-based biomarkers to measure liver function in patients receiving radiation therapy for liver cancer or cancer tha...
Detailed Description
The purpose of this study is to evaluate the role of quantitative MR imaging and blood-based biomarkers to measure liver function in patients receiving radiation therapy for liver cancer or cancer tha...
Eligibility Criteria
Inclusion
- Patient has the psychological ability and general health needed to provide informed consent, completion of study requirements, and required follow-up
- Patient provides study-specific informed consent prior to study entry
- All primary histologies (Hepatocellular carcinoma or Cholangiocarcinoma) as well as hepatic metastases are eligible
- Prior history of radiation therapy (external beam or radioembolization) is allowed, with no limit to the number of prior courses of radiation therapy
- Any number of lesions (with no size limit) of pathologically documented (histologically or cytologically) or radiographically proven tumor/metastasis that are being targeted
- Prior history of chemotherapy, immunotherapy, or targeted biological therapy is allowed
- Concurrent enrollment on other prospective registry or treatment intention trials is allowed
Exclusion
- Pregnant or breast-feeding females
- Subjects with history of claustrophobia impacting ability to perform MRI during the study
- Subjects who fulfill any of the contraindications for MRI; examples include any ferromagnetic material, any metallic shrapnel or fragments or implanted electronic devices contained within the body or metal-containing tattoos
- Unable to participate in MR assessments due to physical limitations of equipment tolerances (MRI bore size and/or weight limit)
- Any person unable to lie still within the environment of the MRI scanner or maintain a breath hold for the required period to acquire images
- Exclusion criteria for HepQuant SHUNT testing ONLY:
- Known history or suspected hypersensitivity to human serum albumin, or its preparations
- Subjects with extensive resection of large segments of small intestine (short gut) or severe gastroparesis
- Subjects on either a non-selective beta blocker (propranolol, nadolol) or an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) who are unwilling or unable to delay taking their normal dose the morning of their testing
- Subjects who are allergic to any ingredient in the formulations or components in the HepQuant SHUNT kit including human serum albumin (HSA) or cholate compounds (theoretical - none yet reported)
- Subjects unwilling or unable to fast for at least 5 hours. Fasting means no intake of food or food supplements, including fiber preparations or biosimilars; or, any preparations or resins (cholestyramine, colestipol, colesalvalem) that might act within the gut lumen to bind the orally administered d4-cholate in the HepQuant test
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2028
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT06144827
Start Date
January 1 2025
End Date
January 1 2028
Last Update
March 18 2025
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