Status:
UNKNOWN
Effects of Glucocortioids in Human Skeletal Muscle, Adipose Tissue and Skin
Lead Sponsor:
University of Aarhus
Conditions:
Glucocorticoids Toxicity
Iatrogenic Effect
Eligibility:
All Genders
55+ years
Phase:
NA
Brief Summary
BACKGROUND: A notorious and dreaded adverse effect of glucocorticoids (GC) is redistribution of muscle and fat mass towards muscle wasting and visceral obesity. Fibroadipogenic progenitors (FAPs) are ...
Detailed Description
Design: randomized, double blind, placebo-controlled trial. The aim is to study the effect of short-term GC exposure on skeletal muscle, skin , adipose tissue in 12 healthy adults above the age of 50 ...
Eligibility Criteria
Inclusion
- Written and oral consent prior to study beginning
- Age of or above 50 years
- Healthy (uncomplicated hypertension and hypercholesteroleamia is accepted)
- BMI of or below 35
Exclusion
- Consumption of glucocorticoid pharmaceuticals (inhalation steroids, intra-articular or intra-muscular injections, steroid creme group IV-V used in the genital area). Allowed pharmaceuticals: ocular drops, nasal sprays/drops, steroid creme group I-III, steroid creme group IV-V used in non-genital areas
- Alcohol consumption of more than 21 units per week
- Consumption of strong CYP3A4 inhibitors/inducers
- Serious comorbidity (heart, liver, or kidney failure, as well as cooncurrent cancer/chemotherapy treatment)
- High daily activity level (more than 30min per day or more than 2 organized workouts per week)
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06145126
Start Date
December 1 2023
End Date
July 1 2025
Last Update
November 22 2023
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