Status:
COMPLETED
Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy
Lead Sponsor:
Clinical Hospital Centre Zagreb
Conditions:
Bleeding
Hemoptysis
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Endobronchial bleeding is a common complication of bronchoscopy. Major bleeding, although rare, can be life threatening and often requires advanced therapeutic interventional pulmonary procedures whic...
Eligibility Criteria
Inclusion
- All patients undergoing diagnostic bronchoscopy with sampling (including transbronchial biopsy, endobronchial forceps biopsy, brushing, transbronchial needle aspiration)
- Signed informed consent
Exclusion
- Any existing contraindication for diagnostic bronchoscopy
- Coagulopathy (PV INR \> 1.3)
- Thrombocytopenia (\<50x10\*9 or anemia (Hgb \<80 g/L)
- DOAC, LMWH or antiplatelet drug therapy
- Thrombophilia, history of pulmonary embolism or deep vein thrombosis
- Contraindication for endobronchial application of adrenaline
- Uncontrolled coronary artery disease, cerebrovascular disease or arrhythmia
- Uncontrolled pulmonary hypertension
- Cardiovascular decompensation
- Severe hypoxia (PaO2 \<60mmHg, SaO2 \<90% with an FiO2 \>=60%)
Key Trial Info
Start Date :
December 18 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 28 2025
Estimated Enrollment :
1013 Patients enrolled
Trial Details
Trial ID
NCT06145191
Start Date
December 18 2023
End Date
March 28 2025
Last Update
August 1 2025
Active Locations (1)
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1
University Hospital Centre Zagreb
Zagreb, Croatia, 10000