Status:
RECRUITING
French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis
Lead Sponsor:
University Hospital, Limoges
Collaborating Sponsors:
National Research Agency, France
Centre de Recherche en biomédecine de Strasbourg INSERM UMR-S1118
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pa...
Detailed Description
ALS is the most frequent adult onset motor neuron disease and is highly variable in terms of clinical features, genetics, and neuropathology. A large body of evidence has demonstrated the importance o...
Eligibility Criteria
Inclusion
- Incident cases included at the time of diagnosis with a definite, probable, probable laboratory-supported, or possible ALS according to El Escorial revised criteria and Gold Coast criteria for early diagnosis.
- Incident ALS cases identified and followed-up in the participant ALS \& Other Motor Neuron Diseases Referral Centres: seven in France and two in Germany.
- Patients who signed the informed consent form.
- Adults aged \>18 years old
Exclusion
- Inability to understand the requirements of the protocol.
- Cognitive inability to sign and comprehend the informed consent form.
- Patients who will not accept Riluzole therapy during their follow-up.
Key Trial Info
Start Date :
September 17 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2029
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06147843
Start Date
September 17 2024
End Date
September 30 2029
Last Update
November 25 2024
Active Locations (7)
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1
CHU de Lille
Lille, France, 59037
2
Limoges University Hospital
Limoges, France, 87042
3
Hôpital de la Timone
Marseille, France, 13005
4
Hôpital Gui Chauliac
Montpellier, France, 34295